Known as one of the fixed-dose combinations for HIV treatment, Combiviris comprised of 150 mg lamivudine and 300 mg zidovudine. This antiretroviral medication comes in the form of a tablet, perfect for adults and children who are at least 14 kgs. This drug can be purchased under the names Lazid and Duovir.
How does this drug work?
Since both of the main components of Combivir (Lamivudine and Zidovudine) are NRTIs, it has the same purpose of blocking HIV infection from multiplying in the entire body system. Defined as nucleoside reverse transcriptase inhibitors, NNRTIswork by inhibiting an enzyme that HIV utilizes in their replication process. This enzyme is known as reverse transcriptase.As the patients continue to take this drug, there is less chance for the infection to progress. The main goal for people with HIV is to achieve an undetectable status. That is why following the right dosage in consuming this medicine is always a prerequisite.
There are certain factors that doctors consider when giving patients the right dosage and prescription. These are as follows:
Pre-existing medical conditions (medical history)
Other forms of medicine that the patients are currently taking
1 tablet (twice a day)
For individuals weighing 30 kgs
½ tablet in the morning
1 tablet in the afternoon
Essentially for children weighing 21kgs-30 kgs
For children weighing 14kgs-21kgs, only take ½ tablet (twice a day)
How to take it?
Swallow this drug with water. Like other medications, it can be taken with or without food. Since children are not capable of consuming a whole tablet, ½ of the whole tablet can be given to them. Another alternative for children is crushing the tablet and mixing it with the water they drink or with the food they eat. This way, the medication is administered easily. Some things need strict observance, especially when taking an HIV medication. Since Combivir is advised to be consumed daily, make sure you have a proper schedule in your daily dosage. Setting the alarm can also help to avoid skipping doses. Other than that, following your doctor’s prescription will always assist you in your treatment process. Avoid practicing an inconsistent dosage. HIV can get worse if you are taking this drug irresponsibly.
Combivir Side Effects
All side effects are categorized based on their level of intensity to the human body. Some can go away very quickly, while some don’t. If these side effects stay longer than expected, call your doctor immediately.
Mild Side Effects:
Severe Side Effects:
Weakness or tiredness
Unusual muscle pain
Light-coloured bowel movements
Loss of appetite
Severe stomach pain
Dizziness or lightheadedness
Tingling in arms and legs
Yellowing of skin and eyes
Keep Combivir away from children. Store it in a place where there is no direct sunlight that can damage its effectiveness, and at the same time keep them dry and warm. If Combivir has expired already, throw it at once.