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What is Complera (Emtricitabine/Rilpivirine/Tenofovir)?

Categorized as one of the fixed-dose combinations of ARV medications, Complera is composed of Emtricitabine (200 mg), Rilpivirine (25 mg), and Tenofovir (300 mg). This medication comes in the form of a tablet, and can be prescribed for individuals who have HIV, whether it be adults or children. Like other HIV treatments, Complera is a widely used drug available on the market today.

How does Complera work?

This medication is a mixture of the two different classes of drugs – NRTIs and NNRTIs. Both of these ARV drugs work by inhibiting the infection from replicating. It blocks HIV from its continued spread in the body. It lessens the emergence of other health concerns, including cancer. It also helps prevent HIV from progressing to AIDS.


Again, just like other ARV medications, Complera observes a series of factors regarding its dosage. These are as follows:
  • An infected person’s age
  • His/her weight
  • Underlying medical conditions aside from HIV
  • Treatment response

Adult and Children Dosage:

  • 1 tablet daily
  • For children, their weight must be 77 pounds

How to take it?

Complera is usually taken with food. Taking it with water is also another option. The common prescription for this type of drug is that it is taken daily. The dosage must be followed rigidly to make sure that you are following the right treatment procedure. Should you forget to consume a tablet for one day, do not ever add a skipped dose for your next scheduled dosage (ie do not double dose if you miss a dose).

Complera Side Effects

Some side effects of this type of medication go away quickly. However, if there are adverse reactions that become severe or last a long time, consult your healthcare professional immediately.

Mild Side Effects: 

  • Sleeping problem
  • Unusual dreams
  • Diarrhea
  • Mild headache
  • Mild rash

Severe Side Effects: 

  • Extreme tiredness
  • Erratic Heartbeat
  • Dizziness
  • Unusual bruising or bleeding
  • Decreased urination
  • Dark or yellow-brown urine
  • Abdominal ache
  • Appetite problem
  • Tingling of the arms or legs
  • Jaundice


Place Complera in storage where it can’t be reached easily by your children. Avoid exposing it to direct sunlight. Preserve the medication by placing it in a safe package. Since medications expire, Complera is not an exception, so dispose of it immediately if it expires.
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