Trizivir (Abacavir/Lamivudine/Zidovudine) Uses and Dosage

What is Trizivir (Abacavir/Lamivudine/Zidovudine)?

Trizivir is a fixed-dose combination of antiretroviral medications, such as Abacavir, Lamivudine, and Zidovudine. It is specifically designed to treat the human immunodeficiency virus and inhibit it from multiplying and spreading in the entire body. This prescription drug comes in the form of an oral tablet.

Trizivir controls HIV infection and decreases the viral load in the body so that the immune system can work properly. Aside from this function, it prevents an infected person to acquire other serious complications caused by the virus, such as cancer. The drug’s generic version is also available, with an efficient performance but cheaper and will cost only a lesser amount of money to the patients.

Trizivir (Abacavir/Lamivudine/Zidovudine) Side Effects

How does Trizivir work?

Abacavir, lamivudine, and zidovudine are both parts of a class of drugs known as nucleoside reverse transcriptase inhibitors or NRTIs. This type of medication controls and manages HIV infection by stopping the virus from making copies of itself. NRTIs like Trizivir slows down the development of the viruses that trigger other infections or complications caused by the human immunodeficiency virus.

In treating HIV, NRTIs work by inhibiting the reverse transcriptase, an enzyme that HIV uses to multiply and spread in the entire body. This process helps the immune system to work properly and fight infections that may lead to AIDS or acquired immunodeficiency syndrome.

Dosage

The right dosage of Trizivir depends on a variety of factors. These are as follows:

• Age of the patient
• Pre-existing medical conditions, such as bone marrow suppression, liver disease, kidney disease, heart disease or high blood pressure, diabetes, and high cholesterol
• Allergy to Trizivir or any ingredients of the drug (this medication is prohibited should the patient has known hypersensitivity to abacavir, lamivudine, and zidovudine)
• The severity of the condition that the medication needs to treat
• Weight of the patient

Take into account the following information with regards to the proper dosage that may be recommended to you by the doctor.

Dosage for HIV

Adult Dose for HIV Infection:

• Take one tablet orally (twice daily)
• Can be taken alone or in combination with other ARV drugs

Adult Dose for Nonoccupational Exposure:

• Take one tablet orally (twice daily)
• 28 days of therapy duration

Adult Dose for Occupational Exposure:

• Take one tablet orally (twice daily)
• 28 days of therapy duration

Pediatric Dose for HIV Infection:

• Children who are at least 25 kg: 1 tablet orally twice a day

Trizivir can be taken with or without food. The doctor will provide the prescription that the patient must follow. To support this, the leaflet provided with the medication is also available. For missed doses, the drug should be taken as the patient can. Frequent visit to the doctor is also highly advisable to control the disease further and keep the patient of his/her progress.

Aside from taking Trizivir, there are other ways in HIV treatment that decrease someone’s risk of getting the infection. These are as follows:

• Safe sex. Utilize the effectiveness of condoms, dental dams, and other barrier methods during sexual activity to prevent HIV transmission.
• Sharing personal items is a big NO. This could lead to HIV transmissions, such as contaminated needles or syringes, used toothbrushes and razors.
• Drug abuse and alcohol abuse could the main reasons for someone to engage in unprotected sex and injection use. Always avoid these risky behaviors.
• Get yourself tested. HIV is controlled through HIV testing. Once the result turns out to be positive, immediate treatment with ART will be given. However, if it’s negative, practicing safe sex and taking PrEP are options.

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